AMN 082, an agonist of mGluR7, exhibits mixed anti- and proconvulsant effects in developing rats
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چکیده
منابع مشابه
AMN 082, an agonist of mGluR7, exhibits mixed anti- and proconvulsant effects in developing rats.
Metabotropic glutamate receptors (mGluRs) represent a potential therapeutic target. Possible anticonvulsant action of AMN 082, an agonist of mGluR7 subtype, was studied in immature rats using pentylenetetrazol (PTZ)-induced seizures as a model. Five age groups of rats (7-, 12-, 18-, 25-day-old and adult animals) were pretreated with AMN 082 in doses of 0.5, 1, 2, and 5 mg/kg i.p. and 30 min lat...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2008
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.931671